Victor Porton's Personal Weblog

I have a new theory of AIDS virus! Well, I'm a complete dilettante in biology and medicine, and all this may be wrong. But if you are a biologist, please read this anyway, it may be indeed right idea and help AIDS curing.

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My theory is: AIDS virus is an antibody.

We all know that what lymphocytes do is producing antibodies. But AIDS virus is also produced by lymphocytes. This is a reason to suppose that AIDS viruses are antibodies. If it is right then it could be said (probably not in the quite correct scientific terms) AIDS viruses are mutant antibodies. (I use scientific terminology in a rather crude way in this phrase, but it is probably essentially like this.)

Additionally to the above I could possibly suppose that AIDS viruses are (inefficient that is not curing) antibodies against itself (against AIDS virus). In other words, I suppose that probably AIDS viruses are produced by cells not in that way as other viruses are produced, but in a different way, namely that they are produced as (inefficient) antibodies against AIDS virus itself. (So AIDS may be probably even not a virus in the traditional meaning of this word, but a unique special kind of auto-immune sickness.)

Then, if the above (or a part of the above) is true or even partially true (near to the truth), to develop a cure against AIDS we could reasonably follow the following model AIDS viruses are antibodies. or stronger model AIDS viruses are antibodies produced against AIDS viruses. In this model AIDS is an autoimmune sickness.

Quite probably (especially because I am a complete dilettante) the above model is wrong. But I suppose indeed that it may have some similarity with the reality. For example AIDS virus is probably a so to say virtual antibody against AIDS virus. That is it may be not being an antibody indeed be synthesized by lymphocytes in an intermediate stage the process of synthesizing antibodies against AIDS antigen. (I'm deem that the modern science cannot say yes or no to my last conjecture without further experiments. For me it looks like quite similar to a truth.)

That is we could replace the question how to fight with AIDS with the question how to fight with mutant antibodies (or similar things)?

The above question could be again replaced with an other question: How to cause certain harmful antibodies to change in such a way that they cease to be harmful?

I suppose that the way to answer to the above question is to change the antigens against which the antibodies are produced. So in my model it is possible that we can cause AIDS viruses to change (probably to change in such a way to become less dangerous) inside a sick organism by adding mutant AIDS viruses (or parts of mutant AIDS viruses) to the blood.

That is we could produce a culture of changed AIDS virus in some way, e.g. by infecting an animal with a mutant AIDS virus or even by adding (changed or partial) AIDS gen to DNA of a bacteria or other not infectible organism. Adding AIDS gen to an ininfectible organism has the advantage that it allows: a. to produce a culture of identical (not further actively mutating) AIDS viruses; b. produce parts (fragments) of AIDS virus.

What we need to produce is a culture of identical (or similar) changed AIDS viruses. Then we could try to use this culture as a cure against AIDS. If this cure will be effective at all, then I suppose that it will be the most effective if the mutant viruses are produced from the viruses borrowed from the same organism which we attempt to cure.

However it also exists even the hope that some mutant culture of AIDS viruses will be an effective cure for all AIDS infected men, not only for one particular infected man from whose body the viruses used to produces artificially mutant viruses were borrowed. If the last will indeed not succeed, then we could anyway try to go through the hard way of curing every particular AIDS infected man with fragments of mutant fragments of the AIDS virus borrowed from his body.

Conclusion: I suggest to attempt to cure AIDS with mutant and/or partial AIDS virus itself.